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Vitamin A Body Pool Size

Vitamin A deficiency is a serious public health problem in most developing countries. Accurate assessment of vitamin A status is necessary to develop and evaluate intervention programmes. The IAEA provides technical support to its Member States to use stable isotope dilution techniques to develop and evaluate programmes aimed at reducing vitamin A deficiency in populations. The stable isotope dilution technique, in contrast to other methods, has the potential to provide a quantitative estimate of vitamin A concentration across the continuum of status, from deficient to excess vitamin A body stores. Please visit the related links for more information on the theoretical background as well as the practical application of the technique of measuring the body vitamin A pool size.


IAEA Publications

Appropriate Uses of Vitamin A Tracer (Stable Isotope) Methodology. The Vitamin A Tracer Task Force, jointly organized by the USAID, HarvestPlus, the International Atomic Energy Agency (IAEA) and the International Life Sciences Institute (ILSI), 2004, 6 pp.
This publication gives a brief overview of the tracer methodology using dilution of stable isotopes.

Handbook on Vitamin A Tracer Dilution Methods to Assess Status and Evaluate Intervention Programs. HarvestPlus Technical Monograph 5. Haskell MJ, Mercado JD, and the Vitamin A Tracer Task Force, Jointly organized by the International Atomic Energy Agency (IAEA), USAID and HarvestPlus, 2005, 23 pp. 
This publication describes in detail the stable isotope dilution technique, presents study protocols and outlines different uses of the technique.

Analysis of Stable Isotope Data to Estimate Vitamin A Body Stores. The Vitamin A Tracer Task Force, Jointly organized by Harvest Plus, the IAEA and USAID. June 2008, 27 pp. International Atomic Energy Agency, Vienna, Austria.
This publication describes model-based compartmental analysis of stable isotope data to estimate vitamin A body stores in humans.


IAEA E-learning modules