Introduction Accelerator-based boron neutron capture therapy (BNCT) has become available for hospitals and there is a rapidly growing interest from the medical community in using it as innovative modality in oncology. Through biological targeting, BNCT offers an approach to overcoming radiation resistance in some types of cancer, as well as a potential cure for locally recurrent solid tumors after maximal conventional therapies. Clinical experience collected in several hundred patients, especially in Finland and Japan, has generated a multitude of activities for hospital-based BNCT centres. In Japan, there are already three facilities treating patients; in Finland, a facility is being commissioned in Helsinki. Scientific societies have been founded on an international and national (Finland, Germany and Japan) level and accelerator-based high intensity epithermal neutron sources have become available. However, the standardization needed for the further development of this modality is lacking. Practical experience of how to plan, execute and hand over an operating BNCT facility, especially to an institution or in a country that has never operated one before, has not yet been gathered together in one place. Objectives The purpose of the event is to assess the current status of the boron neutron capture therapy technique with emphasis on usage of compact accelerator based intense neutron sources. The event also aims to contribute to the update of IAEA-TECDOC-1223. Target Audience The event is aimed at staff from hospitals interested in establishing such a facility; specialists in the process of planning or executing such a project; medical and other scientists performing research and patient treatments for and with BNCT; companies designing and marketing accelerators and beam delivery systems; national standards laboratories in charge of neutron metrology; and regulators. Expected Outputs
The expected output of the event will be a report that covers the developments in the field that have taken place since the publication of Current Status of Neutron Capture Therapy (IAEA-TECDOC-1223), in 2001. The report will give a high-level overview of the standards that need to be developed, as well as the processes and considerations required during project development, execution and handover to operations.
| Structure Due to Covid-19, the meeting was re-organized to be virtual. Talks will be available 2-weeks prior to the meeting. Discussion threads are provided for each talk where you may leave questions and comments. A separate single discussion thread is given for each day. Topics The event will cover topics that form the conceptual table of contents for the final report. They are sorted into the days that will be dealt with in the Webex meeting. Click on the day of your interest and to find your abstract and contributions. The Lead authors for various sections have now been identified. TECDOC section
| Lead Authors
| Day
| Prerequisites for neutron beam parameters
| Iiro Auterninen, Ignacio Porras, David Nigg, Yuan Hao Liu | Monday
| Beam design considerations
| Hiroaki Kumada, Jacek Capala
| Monday
| Physical dosimetry: determination of beam parameters
| Hiroki Tanaka, Daniel Santos | Monday
| Neutron sources for BNCT treatment facilities
| Yoshiaki Kiyanagi, Andres Kreiner | Tuesday
| Organization, operation & management of a treatment facility
| Koji Ono, Yoshihiro Takai | Tuesday
| Treatment facility design
| Liisa Porra, Akira Matsumura Satoshi Nakamura | Tuesday
| Regulatory aspects
| Sandro Rossi, Noah Smick, Shin Masui | Tuesday | Boron compounds
| Evamarie Hey-Hawkins, Hiroyuki Nakamura, Amirreza Jalilian (IAEA) | Wednesday
| Radiobiology
| Saverio Altieri, Susana Nievas, Jun Hatazawa | Wednesday
| Boron concentration determination and imaging
| Hanna Koivunoro, Yoshinori Sakurai | Wednesday
| Prescribing and treatment planning for BNCT
| Wolfgang Sauerwein, Shin-Ichi Miyatake
| Thursday
| Dose reporting in BNCT
| Mandy Schwint – Mitsuko Masutani | Thursday
| Clinical trial design and procedures for BNCT
| Andrea
Wittig, Hiroshi Igaki | Thursday
| Models
of dose calculation in BNCT
| Sara J. González, Silva Bortolussi,Tatsuhiko Sato | Thursday
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