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isouron
Editor	I.G. Ferris
Entity code	ISOUR
CAS registry No.	55861-78-4
Family	Urea derivates
Functions	Herbicide
Chemical name	3-(5-tert-butylisoxazol-3-yl)-1,1-dimethylurea (IUPAC) (EN)
Synonyms
Trade names	Isoxyl (Shionogi); SSH 43 (Shionogi); Conserve (Elanco)
Other names
Last updated	20/5/2003

Fate
Environmental: Some microbial degradation occurs in soil.In plants: Metabolized in plants by two major degradationpathways, N-demethylation or hydroxylation of the tert-butyl group.

Toxicology
Mammals:Acute oral LD50 for rats 630-760, mice 520-530 mg/kg.Acute percutaneous LD50 for rats >5000 mg/kg. Non-irritating to skin; slight eye irritant (rabbits). Acute i.p. LD50 for rats 270 mg/kg. Acute inhalation LC50 for rats >0.415 mg/l air (8 hours). In 2-year feeding trials, no-effect level for rats was 7.26-8.77 mg/kg/day, and for mice 3.42-16.6 mg/kg/day. Birds: Acute oral LD50 for bobwhite quail >2000 mg/kg. Fish: LC50 for carp 78.7, Japanese killifish 173.0 mg/l (48 hours); bluegill sunfish ca. 140, rainbow trout 110-140 mg/l (96 hours). Bees: Non-toxic to bees.

Detection

Sampling

Methods

MRLs

Uses

Mode of action: Selective systemic herbicide, absorbed principally by the roots, with translocation. Inhibits photosynthesis.

Uses: Pre- and post-emergence control of broad-leaved and grassweeds in sugar cane, pineapples etc. Also used for totalweed control on non-crop land.

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Bibliography

Mode of action

Ecotoxicology

Plant metabolism & residues

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